RT Journal Article
T1 Complexity changes in preclinical Alzheimer’s disease: An MEG study of subjective cognitive decline and mild cognitive impairment
A1 Shumbayawonda, Elizabeth
A1 López Sanz, David
A1 Bruña Fernández, Ricardo
A1 Serrano Martínez, Noelia
A1 Fernández Lucas, Alberto Amable
A1 Maestu Unturbe, Fernando
A1 Abásolo, Daniel
AB ObjectiveTo analyse magnetoencephalogram (MEG) signals with Lempel-Ziv Complexity (LZC) to identify the regions of the brain showing changes related to cognitive decline and Alzheimeŕs Disease (AD).MethodsLZC was used to study MEG signals in the source space from 99 participants (36 male, 63 female, average age: 71.82 ± 4.06) in three groups (33 subjects per group): healthy (control) older adults, older adults with subjective cognitive decline (SCD), and adults with mild cognitive impairment (MCI). Analyses were performed in broadband (2–45 Hz) and in classic narrow bands (theta (4–8 Hz), alpha (8–12 Hz), low beta (12–20 Hz), high beta (20–30 Hz), and, gamma (30–45 Hz)).ResultsLZC was significantly lower in subjects with MCI than in those with SCD. Moreover, subjects with MCI had significantly lower MEG complexity than controls and SCD subjects in the beta frequency band. Lower complexity was correlated with smaller hippocampal volumes.ConclusionsBrain complexity – measured with LZC – decreases in MCI patients when compared to SCD and healthy controls. This decrease is associated with a decrease in hippocampal volume, a key feature in AD progression.SignificanceThis is the first study to date characterising the changes of brain activity complexity showing the specific spatial pattern of the alterations as well as the morphological correlations throughout preclinical stages of AD.
PB Elsevier
SN 1388-2457
YR 2020
FD 2020-02
LK https://hdl.handle.net/20.500.14352/94979
UL https://hdl.handle.net/20.500.14352/94979
LA eng
DS Docta Complutense
RD 7 abr 2025