%0 Journal Article
%A Aranaz Martín, Alicia
%A Romero Martínez, Beatriz
%A Montero Serra, Natalia
%A Álvarez Sánchez, Julio
%A Bezos Garrido, Javier
%A Juan Ferré, Lucía De
%A Mateos García, Ana Isabel
%A Domínguez Rodríguez, Lucas José
%T Spoligotyping Profile Change Caused by Deletion of a Direct Variable Repeat in a Mycobacterium tuberculosis Isogenic Laboratory Strain
%D 2004
%@ 0095-1137
%@ 1098-660X
%U https://hdl.handle.net/20.500.14352/93502
%X Spoligotyping is a major tool for molecular typing of Mycobacterium tuberculosis complex organisms. For epidemiological purposes, strains are considered clonal only when their spoligotyping patterns are identical. We report a change in the spoligotyping profiles of truly isogenic strains (a clinical isolate and a subculture derived in the laboratory) caused by deletion of a direct variable repeat. Without the information about the relationship between them, a link between these strains would have gone unnoticed. Evolutionary events should be taken into account in the interpretation of spoligotyping results and in the design of databases.
%~