RT Journal Article
T1 Spoligotyping Profile Change Caused by Deletion of a Direct Variable Repeat in a Mycobacterium tuberculosis Isogenic Laboratory Strain
A1 Aranaz Martín, Alicia
A1 Romero Martínez, Beatriz
A1 Montero Serra, Natalia
A1 Álvarez Sánchez, Julio
A1 Bezos Garrido, Javier
A1 Juan Ferré, Lucía De
A1 Mateos García, Ana Isabel
A1 Domínguez Rodríguez, Lucas José
AB Spoligotyping is a major tool for molecular typing of Mycobacterium tuberculosis complex organisms. For epidemiological purposes, strains are considered clonal only when their spoligotyping patterns are identical. We report a change in the spoligotyping profiles of truly isogenic strains (a clinical isolate and a subculture derived in the laboratory) caused by deletion of a direct variable repeat. Without the information about the relationship between them, a link between these strains would have gone unnoticed. Evolutionary events should be taken into account in the interpretation of spoligotyping results and in the design of databases.
PB American Society for Microbiology
SN 0095-1137
SN 1098-660X
YR 2004
FD 2004-06-23
LK https://hdl.handle.net/20.500.14352/93502
UL https://hdl.handle.net/20.500.14352/93502
LA eng
NO Aranaz, A., Romero, B., Montero, N., Alvarez, J., Bezos, J., de Juan, L., Mateos, A., & Domínguez, L. (2004). Spoligotyping profile change caused by deletion of a direct variable repeat in a Mycobacterium tuberculosis isogenic laboratory strain. Journal of clinical microbiology, 42(11), 5388–5391. https://doi.org/10.1128/JCM.42.11.5388-5391.2004
NO Autor de correspondencia: Alicia Aranaz;2004, American Society for Microbiology. All Rights Reserved.Financiación: Ramon y Cajal Program (Spanish Ministry of Science and Technology).Pproject AGL 2001-2029 of the Spanish Ministry of Science and Technology and by the Spanish Ministry of Agriculture, Fisheries and Food (MAPA).
NO Ministerio de Ciencia y Tecnología
NO Project AGL 2001-2029
NO Ministerio de Agricultura, Pesca y Alimentación
DS Docta Complutense
RD 1 sept 2024