RT Journal Article
T1 Canine cell line, IPC‐366, as a good model for the study of inflammatory breast cancer
A1 Cáceres Ramos, Sara Cristina
A1 Peña Fernández, Laura Luisa
A1 Lacerda, Lara
A1 Illera del Portal, Josefina María
A1 Andrés Gamazo, Paloma Jimena de
A1 Larson, Richard
A1 Gao, Hui
A1 Debeb, Bisrat
A1 Woodward, Wendy
A1 Reuben, James
A1 Illera Del Portal, Juan Carlos
AB Inflammatory breast cancer (IBC) is an aggressive type of cancer with poor survival in women. Inflammatory mammary cancer (IMC) in dogs is very similar to human IBC and it has been proposed as a good surrogate model for study the human disease. The aim was to determine if IPC-366 shared characteristics with the IBC cell line SUM149. The comparison was conducted in terms of ability to grow (adherent and nonadherent conditions), stem cell markers expression using flow cytometry, protein production using western blot and tumorigenic capacity. Our results revealed that both are capable of forming long-term mammospheres with a grape-like morphology. Adherent and nonadherent cultures exhibited fast growth in vivo. Stem cell markers expressions showed that IPC-366 and SUM149 in adherent and nonadherent conditions has mesenchymal-like characteristics, E-cadherin and N-cadherin, was higher in adherent than in nonadherent cultures. Therefore, this study determines that both cell lines are similar and IPC-366 is a good model for the human and canine disease.
PB Wiley
SN 1476-5810
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/95546
UL https://hdl.handle.net/20.500.14352/95546
LA eng
NO Caceres S, Peña L, Lacerda L, Illera MJ, de Andres PJ, Larson RA, Gao H, Debeb BG, Woodward WA, Reuben JM, Illera JC. Canine cell line, IPC-366, as a good model for the study of inflammatory breast cancer. Vet Comp Oncol. 2017 Sep;15(3):980-995. doi: 10.1111/vco.12238. Epub 2016 May 5. PMID: 27146723.
NO Ministerio de Educación y Ciencia (España)
DS Docta Complutense
RD 6 abr 2025