TY - JOUR AU - Mikkelsen, Kasper AU - Harwood, Seandean Lykke AU - Compte, Marta AU - Merino, Nekane AU - Mølgaard, Kasper AU - Lykkemark, Simon AU - Álvarez Méndez, Ana María AU - Blanco, Francisco J. AU - Álvarez Vallina, Luis PY - 2019 DO - 10.3389/fimmu.2019.01791 UR - https://hdl.handle.net/20.500.14352/108540 T2 - Frontiers in Immunology AB - 4-1BB (CD137) is an inducible costimulatory receptor that promotes expansion and survival of activated T cells; and IgG-based 4-1BB-agonistic monoclonal antibodies exhibited potent antitumor activity in clinical trials. However, the clinical... LA - eng M2 - 1 PB - Frontiers Media KW - cancer immunotherapy KW - immunostimulatory antibodies KW - costimulation KW - 4-1BB KW - 4-1BB agonists KW - trimerbodies KW - CEA KW - CEA-targeted 4-1BB agonists TI - Carcinoembryonic Antigen (CEA)-Specific 4-1BB-Costimulation Induced by CEA-Targeted 4-1BB-Agonistic Trimerbodies TY - journal article VL - 10 ER -