RT Journal Article
T1 Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome
A1 Caso Fernández, Javier Rubén
A1 Hurtado Moreno, Olivia
A1 Pereira, Marta P.
A1 García Bueno, Borja
A1 Menchén Viso, Luis Alberto
A1 Alou Cervera, Luis
A1 Gómez-Lus Centelles, María Luisa
A1 Moro Sánchez, María Ángeles
A1 Lizasoaín Hernández, Ignacio
A1 Leza Cerro, Juan Carlos
AB Stress is known to be one of the risk factors of stroke, but only a few experimental studies have examined the possible mechanisms by which prior stress may affect stroke outcome. In stroke patients, infections impede neurological recovery and increase morbidity as well as mortality. We previously reported that stress induces a bacterial translocation and that prior immobilization stress worsens experimental stroke outcome through mechanisms that involve inflammatory mediators such as release of proinflammatory cytokines and enzyme activation. We now investigate whether bacterial translocation from the intestinal flora of rats with stress before experimental ischemia is involved in stroke outcome. We used an experimental paradigm consisting of exposure of Fischer rats to repeated immobilization sessions before permanent middle cerebral artery occlusion (MCAO). The presence of bacteria and the levels and expression of different mediators involved in the bacterial translocation were analyzed. Our results indicate that stress before stroke is related to the presence of bacteria in different organs (mesenteric nodes, spleen, liver, and lung) after MCAO and increases inflammatory colonic parameters (such as cyclooxygenase-2, inducible nitric oxide synthase, and myeloperoxidase), but decreases colonic immunoglobulin A, and these results are correlated with colonic inflammation and bacterial translocation. Understanding the implication of bacterial translocation during stress-induced stroke worsening is of great potential clinical relevance, given the high incidence of infections after severe stroke and their main role in mortality and morbidity in stroke patients.
PB American Physiological Society
SN 0363-6119
YR 2009
FD 2009-04
LK https://hdl.handle.net/20.500.14352/107128
UL https://hdl.handle.net/20.500.14352/107128
LA eng
NO Caso JR, Hurtado O, Pereira MP, García-Bueno B, Menchén L, Alou L, Gómez-Lus ML, Moro MA, Lizasoain I, Leza JC. Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome. Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R979-85.
DS Docta Complutense
RD 29 sept 2024