RT Journal Article
T1 S-nitrosylation: a potential new paradigm in signal transduction
A1 Martínez Ruiz, Antonio
A1 Lamas, Santiago
AB Much attention has been paid to nitric oxide (NO) research since its discovery as a physiological mediator in the cardiovascular system. Inrecent years, newer roles have been attributed to this molecule and its close relatives, termed collectively reactive nitrogen species (RNS).These roles relate to different mechanisms of protein modification, among which S-nitrosylation of cysteines has emerged as a potential newparadigm in signal transduction and regulation of protein function. We review here the chemical basis of this modification compared withother protein modifications related to nitric oxide, as well as the kind of specificity we can expect from it. We also review the currentmethodologies that can be applied to the study of S-nitrosylation and identification of S-nitrosylated proteins in cells, and detail the relevanceof this modification in several proteins related to cardiovascular system.
SN 0008-6363
YR 2004
FD 2004-04-01
LK https://hdl.handle.net/20.500.14352/102710
UL https://hdl.handle.net/20.500.14352/102710
LA eng
NO Plan Nacional de I + D + I, Ministerio de Ciencia y Tecnología
NO Comunidad Autónoma de Madrid (08.4/0030.1/2003)
NO Ministerio de Sanidad (RECAVA network)
DS Docta Complutense
RD 28 jul 2024