%0 Journal Article
%A Perez-Perez, Silvia
%A Dominguez-Mozo, Maria Inmaculada
%A Alonso-Gomez, Aitana
%A Medina, Silvia
%A Villarubia, Noelia
%A Fernandez-Velasco, Jose Ignacio
%A Garcia-Martinez, Maria Angel
%A Garcia-Calvo, Estefania
%A Estévez Sánchez, Héctor
%A Costa-Frossard, Luciene
%A Alvarez-Cermeño, Jose C.
%A Luque García, José Luis
%A Arroyo, Rafael
%A Villar, Luisa M.
%A Alvarez-Lafuente, Roberto
%T Acetate correlates with disability and immune response in multiple sclerosis
%D 2020
%U https://hdl.handle.net/20.500.14352/105862
%X Background. Gut microbiota has been related to multiple sclerosis (MS) etiopathogenesis. Short-chain fatty acids (SCFA) are compounds derived from microbial metabolismthat have a role in gut-brain axis.Objectives. To analyse SCFA levels in plasma of MS patients and healthy donors (HD),and the possible link between these levels and both clinical data and immune cellpopulations.Methods. Ninety-five MS patients and 54 HD were recruited. Patients were selectedaccording to their score in the Expanded Disability Status Scale (EDSS) (49 EDSS ≤ 1.5,46 EDSS ≥ 5.0). SCFA were studied in plasma samples by liquid chromatography-massspectrometry. Peripheral blood mononuclear cells were studied by flow cytometry.Gender, age, treatments, EDSS and Multiple Sclerosis Severity Score (MSSS) wereevaluated at the recruitment.Results. Plasma acetate levels were higher in patients than in HD (p = 0.003). Patientswith EDSS ≥ 5.0 had higher acetate levels than those with EDSS≤ 1.5 (p = 0.029),and HD (p = 2.97e–4). Acetate levels correlated with EDSS (r = 0.387; p = 1.08e–4)and MSSS (r = 0.265;p = 0.011). In untreated MS patients, acetate levels correlatedinversely with CD4+ naïve T cells (r = −0.550,p = 0.001) and directly with CD8+IL-17+ cells (r = 0.557;p = 0.001).Conclusions. Plasma acetate levels are higher in MS patients than in HD. In MS thereexists a correlation between plasma acetate levels, EDSS and increased IL-17+ T cells.Future studies will elucidate the role of SCFA in the disease.
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