RT Journal Article
T1 Acetate correlates with disability and immune response in multiple sclerosis
A1 Perez-Perez, Silvia
A1 Dominguez-Mozo, Maria Inmaculada
A1 Alonso-Gomez, Aitana
A1 Medina, Silvia
A1 Villarubia, Noelia
A1 Fernandez-Velasco, Jose Ignacio
A1 Garcia-Martinez, Maria Angel
A1 Garcia-Calvo, Estefania
A1 Estévez Sánchez, Héctor
A1 Costa-Frossard, Luciene
A1 Alvarez-Cermeño, Jose C.
A1 Luque García, José Luis
A1 Arroyo, Rafael
A1 Villar, Luisa M.
A1 Alvarez-Lafuente, Roberto
AB Background. Gut microbiota has been related to multiple sclerosis (MS) etiopathogenesis. Short-chain fatty acids (SCFA) are compounds derived from microbial metabolismthat have a role in gut-brain axis.Objectives. To analyse SCFA levels in plasma of MS patients and healthy donors (HD),and the possible link between these levels and both clinical data and immune cellpopulations.Methods. Ninety-five MS patients and 54 HD were recruited. Patients were selectedaccording to their score in the Expanded Disability Status Scale (EDSS) (49 EDSS ≤ 1.5,46 EDSS ≥ 5.0). SCFA were studied in plasma samples by liquid chromatography-massspectrometry. Peripheral blood mononuclear cells were studied by flow cytometry.Gender, age, treatments, EDSS and Multiple Sclerosis Severity Score (MSSS) wereevaluated at the recruitment.Results. Plasma acetate levels were higher in patients than in HD (p = 0.003). Patientswith EDSS ≥ 5.0 had higher acetate levels than those with EDSS≤ 1.5 (p = 0.029),and HD (p = 2.97e–4). Acetate levels correlated with EDSS (r = 0.387; p = 1.08e–4)and MSSS (r = 0.265;p = 0.011). In untreated MS patients, acetate levels correlatedinversely with CD4+ naïve T cells (r = −0.550,p = 0.001) and directly with CD8+IL-17+ cells (r = 0.557;p = 0.001).Conclusions. Plasma acetate levels are higher in MS patients than in HD. In MS thereexists a correlation between plasma acetate levels, EDSS and increased IL-17+ T cells.Future studies will elucidate the role of SCFA in the disease.
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/105862
UL https://hdl.handle.net/20.500.14352/105862
LA eng
NO Pérez-Pérez S, Domínguez-Mozo MI, Alonso-Gómez A, Medina S, Villarrubia N, Fernández-Velasco JI, García-Martínez MÁ, García-Calvo E, Estévez H, Costa-Frossard L, Alvarez-Cermeño JC, Luque-Garcia JL, Arroyo R, Villar LM, Alvarez-Lafuente R. 2020. Acetate correlates with disability and immune response in multiple sclerosis. PeerJ 8:e10220 https://doi.org/10.7717/peerj.10220
DS Docta Complutense
RD 26 dic 2025