RT Journal Article
T1 Socialization causes long-lasting behavioral changes
A1 Gil Martí, Beatriz
A1 Isidro Mézcua, Julia
A1 Poza Rodríguez, Adriana
A1 Asti Tello, Gerson S.
A1 Treves, Gaia
A1 Turiégano, Enrique
A1 Beckwith, Esteban J.
A1 Martín Castro, Francisco Antonio
AB In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, social interaction also has profound effects on animal and human, impacting aggressiveness, feeding and sleep, among many other behaviors. Here, we observe that in the fly Drosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. These modified behaviors maintain similar levels for 24 h and persist up to 72 h, although showing a progressive decay. We also find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.
PB Nature Research
YR 2024
FD 2024-09
LK https://hdl.handle.net/20.500.14352/125995
UL https://hdl.handle.net/20.500.14352/125995
LA eng
NO Gil-Martí, B., Isidro-Mézcua, J., Poza-Rodriguez, A. et al. Socialization causes long-lasting behavioral changes. Sci Rep 14, 22302 (2024). https://doi.org/10.1038/s41598-024-73218-w
NO FundingFAM was a recipient of a RyC-2014-14961 contract (2016-2022). Grant RyC-2014-14961 funded by MICIU/AEI/10.13039/501100011033 and by ESF Investing in your future. Grant CNS2022-135223 funded by MICIU/AEI/10.13039/501100011033 and by European Union NextGeneration EU/PRTR. Grant PID2022-142742NB-I00 funded by MICIU/AEI/10.13039/501100011033 and by ERDF/EU. BG-M is a recipient of a FPI-UAM predoctoral fellowship, grant number SFPI/2020/00878. JIM was a recipient of a JAE intro fellowship (grant number JAEINT_22_01271) funded by the Spanish National Research Council (CSIC).EJB is a member of the Argentine Research Council (CONICET), and he is funded by International Brain Organization (IBRO), Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación, Argentina, through grants PICT-2020-SERIEA-01240, PICT-PRH-2021-00009, and CONICET through grant PIP 11220200102510CO.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.
NO European Commission
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Agencia Estatal de Investigación (España)
NO Consejo Superior de Investigaciones Científicas (España)
NO Universidad Autónoma de Madrid (España)
NO Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina)
NO Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Argentina)
NO International Brain Research Organization
DS Docta Complutense
RD 30 dic 2025