TY - JOUR AU - Bartolomé, Alberto AU - Kimura-Koyanagi, Maki AU - Asahara, Shun-Ichiro AU - Guillén Viejo, Carlos AU - Inoue, Hiroyuki AU - Teruyama, Kyoko AU - Shimizu, Shinobu AU - Kanno, Ayumi AU - García Aguilar, Ana AU - Koike, Masato AU - Uchiyama, Yasuo AU - Benito, Manuel AU - Noda, Tetsuo AU - Kido, Yoshiaki PY - 2014 DO - 10.2337/db13-0970 UR - https://hdl.handle.net/20.500.14352/115487 T2 - Diabetes AB - Hyperactivation of the mammalian target of rapamycin complex 1 (mTORC1) in β-cells is usually found as a consequence of increased metabolic load. Although it plays an essential role in β-cell compensatory mechanisms, mTORC1 negatively regulates... LA - eng M2 - 2996 PB - American Diabetes Association TI - Pancreatic b-Cell failure mediated by mTORC1 hyperactivity and autophagic impairment TY - journal article VL - 63 ER -