%0 Journal Article
%A Antón Hurtado, Olga María
%A Peterson, Mary 
%A Hollander, Michael 
%A Dorward, David 
%A Arora, Gunjan
%A Traba, Javier
%A Rajagopalan, Sumati
%A Snapp, Erik 
%A Garcia, Christopher
%A Waldmann, Thomas 
%A Long, Eric 
%T Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation
%D 2019
%@ 0027-8424
%U https://hdl.handle.net/20.500.14352/96970
%X Interleukin 15 (IL-15) is essential for natural killer (NK) cell survival and proliferation. The IL-15 receptor consists of 3 subunits: the α chain and the β and common γ  chains, which are shared with the IL-2 receptor. NK cells express the β-γchains and are activated in trans by cells presenting IL-15 bound to IL-15Rα, such as dendritic cells. We show here that the release of soluble IL-15Rα–IL-15 complex from presenting cells contributes to efficient signaling for NK cell survival, whereas uptake of the entire membrane-associated-IL-15Rα–IL-15 complex from presenting cells into NK cells contributes to proliferation. Thus, outcomes are dictated not only by signal strength, but also by location where IL-15 trans-presentation occurs in NK cells.
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