RT Journal Article
T1 Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation
A1 Antón Hurtado, Olga María
A1 Peterson, Mary
A1 Hollander, Michael
A1 Dorward, David
A1 Arora, Gunjan
A1 Traba, Javier
A1 Rajagopalan, Sumati
A1 Snapp, Erik
A1 Garcia, Christopher
A1 Waldmann, Thomas
A1 Long, Eric
AB Interleukin 15 (IL-15) is essential for natural killer (NK) cell survival and proliferation. The IL-15 receptor consists of 3 subunits: the α chain and the β and common γ  chains, which are shared with the IL-2 receptor. NK cells express the β-γchains and are activated in trans by cells presenting IL-15 bound to IL-15Rα, such as dendritic cells. We show here that the release of soluble IL-15Rα–IL-15 complex from presenting cells contributes to efficient signaling for NK cell survival, whereas uptake of the entire membrane-associated-IL-15Rα–IL-15 complex from presenting cells into NK cells contributes to proliferation. Thus, outcomes are dictated not only by signal strength, but also by location where IL-15 trans-presentation occurs in NK cells.
PB National Academy of Sciences
SN 0027-8424
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/96970
UL https://hdl.handle.net/20.500.14352/96970
LA eng
NO Anton, Olga M., et al. «Trans -Endocytosis of Intact IL-15Rα–IL-15 Complex from Presenting Cells into NK Cells Favors Signaling for Proliferation». Proceedings of the National Academy of Sciences, vol. 117, n.o 1, enero de 2020, pp. 522-31. https://doi.org/10.1073/pnas.1911678117.
NO National Institute of Health (USA)
NO National Institute of Allergy and Infectious Diseases (USA)
NO National Cancer Institute (USA)
DS Docta Complutense
RD 18 abr 2025