RT Journal Article
T1 Magnetoencephalographic parietal δ dipole density in mild cognitive impairment: Preliminary results of a method to estimate the risk of developing Alzheimer disease
A1 Fernández Lucas, Alberto Amable
A1 Turrero Nogués, Agustín
A1 Zuluaga Arias, María del Pilar
A1 Gil Gregorio, Pedro
A1 Maestu Unturbe, Fernando
A1 Campo, Pablo
A1 Ortiz, Tomás
AB Background: Subjects with mild cognitive impairment (MCI) are at a higher risk of experiencing Alzheimer disease (AD). Magnetoencephalographic temporoparietal dipole densities of low-frequency activity are good predictors of individuals' cognitive status, and might be a useful tool to investigate the conversion from MCI to AD.Objective: To investigate the role of low-frequency dipole densities as predictors of the risk of developing AD.Design: Whole-head magnetoencephalographic recordings were obtained from 19 probable AD patients, 17 MCI patients, and 17 healthy control subjects. The generators of focal magnetic slow waves were located using a single moving dipole model.Results: Left parietal δ dipole density permitted a reliable classification of AD and MCI patients. The MCI patients were divided into 2 groups based on the median left parietal δ dipole density, and were followed up for 2 years. The estimated relative risk of conversion to AD was increased by 350% in those MCI patients with high left parietal δ dipole density scores.Conclusions: Results confirmed the important role of parietal δ dipole density in the evaluation of AD and MCI. A magnetoencephalographic-based assessment of AD and MCI patients might be considered a useful clinical test in the near future.
PB American Medical Association
SN 0003-9942
YR 2006
FD 2006-03
LK https://hdl.handle.net/20.500.14352/51431
UL https://hdl.handle.net/20.500.14352/51431
NO Fernández Lucas, A. A., Turrero Nogués, A., Zuluaga Arias, M. P. et al. «Magnetoencephalographic Parietal δ Dipole Density in Mild Cognitive Impairment: Preliminary Results of a Method to Estimate the Risk of Developing Alzheimer Disease». Archives of Neurology, vol. 63, n.o 3, marzo de 2006, p. 427. DOI.org (Crossref), https://doi.org/10.1001/archneur.63.3.427.
NO Ministerio de Educación, Formación Profesional y Deportes (España)
DS Docta Complutense
RD 4 abr 2025