RT Journal Article
T1 A versatile fluorescent molecular probe endowed with singlet oxygen generation under white-light photosensitization
A1 Durán Sampedro, Gonzalo
A1 Epelde Elezcano, Nerea
A1 Martínez Martínez, Virginia
A1 Esnal Martínez, Ixone
A1 Bañuelos Prieto, Jorge
A1 García Moreno, Inmaculada
A1 Rodríguez Agarrabeitia, Antonia
A1 Moya Cerero, Santiago de la
A1 Tabero Truchado, Andrea
A1 Lázaro Carrillo, Ana
A1 Villanueva Oroquieta, Ángeles
A1 Ortíz García, María Josefa
A1 López Arbeloa, Íñigo María
AB Despite fluorescent photodynamic therapy (fluorescent-PDT) dyes are promising theranostic agents, current approaches unfortunately involve crucial shortcomings (such as, narrow absorption bands, high cost, low bio-compatibility and specificity, low dual efficiency) making difficult their clinical translation. Particularly, efficient fluorescent-PDT agents triggered under white-light, with potential application in topic solar treatments, are scarce. Here, we describe the rational development of a novel fluorescent-PDT molecular biomaterial based on BODIPY building blocks able to sustain, simultaneously, synthetic accessibility, high fluorescence and phototoxicity within a broad spectral window, biocompatibility, including low dark toxicity and high cell permeability with selective accumulation in lysosomes and, what is more important, excellent efficient activity triggered under white light. These all-in-one combined properties make the new dye a valuable ground platform for the development of future smarter theranostic agents.
PB Elsevier
SN 0143-7208
YR 2017
FD 2017-07-01
LK https://hdl.handle.net/20.500.14352/18152
UL https://hdl.handle.net/20.500.14352/18152
LA eng
NO Received 30 January 2017, Revised 10 March 2017, Accepted 11 March 2017, Available online 12 March 2017.
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
NO Gobierno Vasco
DS Docta Complutense
RD 1 sept 2024