%0 Journal Article %A Alou Cervera, Luis %A Ramirez, Mario %A Garcı́a-Rey, César %A Prieto Prieto, José %A de Lencastre, Hermı́nia %T Streptococcus pneumoniae Isolates with Reduced Susceptibility to Ciprofloxacin in Spain: Clonal Diversity and Appearance of Ciprofloxacin-Resistant Epidemic Clones %D 2001 %@ 0066-4804 %@ 1098-6596 %U https://hdl.handle.net/20.500.14352/107054 %X ABSTRACTAnalysis of the pulsed-field gel electrophoretic profiles of 82 pneumococcal isolates with reduced susceptibility to ciprofloxacin (RSC) and of 90 co-occurring susceptible isolates indicates a considerable genetic diversity among isolates with RCS and points to a close relation between the two groups. This finding suggests that pneumococci with RCS emerge through independent mutational events. %~