%0 Journal Article
%A Guerra Pérez, Natalia
%A Ramos, Edurne
%A García-Hernández, Marta
%A Pinto, Celia
%A Soto, Manuel
%A Martín, Elena
%A González, Victor Manuel
%T Molecular and Functional Characterization of ssDNA Aptamers that Specifically Bind Leishmania infantum PABP
%D 2015
%@ 1932-6203
%U https://hdl.handle.net/20.500.14352/97881
%X A poly (A)-binding protein from Leishmania infantum (LiPABP) has been recently cloned and characterized in our laboratory. Although this protein shows a very high homology with PABPs from other eukaryotic organisms including mammals and other parasites, exist divergences along the sequence that convert them in potential diagnostic markers and/or therapeutics targets. Aptamers are oligonucleotide ligands that are selected in vitro by their affinity and specificity for the target as a consequence of the particular tertiary structure that they are able to acquire depending on their sequence. Development of high-affinity molecules with the ability to recognize specifically Leishmania proteins is essential for the progress of this kind of study.
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