RT Journal Article
T1 Molecular and Functional Characterization of ssDNA Aptamers that Specifically Bind Leishmania infantum PABP
A1 Guerra Pérez, Natalia
A1 Ramos, Edurne
A1 García-Hernández, Marta
A1 Pinto, Celia
A1 Soto, Manuel
A1 Martín, Elena
A1 González, Victor Manuel
AB A poly (A)-binding protein from Leishmania infantum (LiPABP) has been recently cloned and characterized in our laboratory. Although this protein shows a very high homology with PABPs from other eukaryotic organisms including mammals and other parasites, exist divergences along the sequence that convert them in potential diagnostic markers and/or therapeutics targets. Aptamers are oligonucleotide ligands that are selected in vitro by their affinity and specificity for the target as a consequence of the particular tertiary structure that they are able to acquire depending on their sequence. Development of high-affinity molecules with the ability to recognize specifically Leishmania proteins is essential for the progress of this kind of study.
PB Public Library of Science
SN 1932-6203
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/97881
UL https://hdl.handle.net/20.500.14352/97881
LA eng
NO Guerra-Pérez N, Ramos E, GarcíaHernández M, Pinto C, Soto M, Martín ME, et al. (2015) Molecular and Functional Characterization of ssDNA Aptamers that Specifically Bind Leishmania infantum PABP. PLoS ONE 10(10): e0140048
NO Ministerio de Economia y Competitividad (España)
DS Docta Complutense
RD 25 mar 2026