RT Journal Article
T1 Possible Allergenic Role of Tropomyosin in Patients with Adverse Reactions after Fish Intake
A1 Alguacil-Guillén, Marina
A1 Daschner, Alvaro
A1 González Fernández, Juan
A1 Cuéllar Del Hoyo, María Del Carmen
AB In a recent case report, patient's anti-fish tropomyosin IgE was associated with gastrointestinal symptoms. We aimed to demonstrate on a wider scale that the panallergen tropomyosin should not be limited to invertebrate species and that clinically relevant reactions could be elicited by vertebrate tropomyosin. On the whole, 19 patients with adverse reactions after fish intake and showing negative skin tests with commercial fish extracts were included. Fish tropomyosin was recognized by 10/19 patients' IgE by immunoblotting. All patients with gastrointestinal complaints after fish intake (6/6) showed an IgE band matching with tropomyosin. Cod, albacore, and swordfish tropomyosins were recognized by most patients although 3/10 patients did not claim adverse reactions to these fish species. Immunoblotting with a battery of antigens from different fish species have a high yield of positivity at a band matching with tropomyosin molecular weight, even if they have not been claimed to be causative agents of symptoms. Tropomyosin is therefore a good candidate to be investigated as a clinically relevant fish allergen in patients who report adverse reactions after fish intake.
PB Taylor and Francis Group
SN 0882-0139
YR 2018
FD 2018-03-26
LK https://hdl.handle.net/20.500.14352/94093
UL https://hdl.handle.net/20.500.14352/94093
LA eng
NO González-Fernández J, Alguacil-Guillén M, Cuéllar C, Daschner A. Possible Allergenic Role of Tropomyosin in Patients with Adverse Reactions after Fish Intake. Immunol Invest. 2018 May;47(4):416-429.
DS Docta Complutense
RD 10 sept 2024