RT Journal Article
T1 Eradication of bovine tuberculosis at a herd-level in Madrid, Spain: study of within-herd transmission dynamics over a 12 year period
A1 Alvarez, Julio
A1 Perez, Andres M
A1 Bezos Garrido, Javier
A1 Casal, Carmen
A1 Romero Martínez, Beatriz
A1 Rodriguez Campos, Sabrina
A1 Saez Llorente, Jose L
A1 Diaz, Rosa
A1 Carpintero, Jesus
A1 Juan Ferré, Lucía De
A1 Álvarez Sánchez, Julio
A1 Domínguez Rodríguez, Lucas José
AB BACKGROUNDEradication of bovine tuberculosis (bTB) through the application of test-and-cull programs is a declared goal of developed countries in which the disease is still endemic. Here, longitudinal data from more than 1,700 cattle herds tested during a 12 year-period in the eradication program in the region of Madrid, Spain, were analyzed to quantify the within-herd transmission coefficient (β) depending on the herd-type (beef/dairy/bullfighting). In addition, the probability to recover the officially bTB free (OTF) status in infected herds depending on the type of herd and the diagnostic strategy implemented was assessed using Cox proportional hazard models.RESULTSOverall, dairy herds showed higher β (median 4.7) than beef or bullfighting herds (2.3 and 2.2 respectively). Introduction of interferon-gamma (IFN-γ) as an ancillary test produced an apparent increase in the β coefficient regardless of production type, likely due to an increase in diagnostic sensitivity. Time to recover OTF status was also significantly lower in dairy herds, and length of bTB episodes was significantly reduced when the IFN-γ was implemented to manage the outbreak.CONCLUSIONSOur results suggest that bTB spreads more rapidly in dairy herds compared to other herd types, a likely cause being management and demographic-related factors. However, outbreaks in dairy herds can be controlled more rapidly than in typically extensive herd types. Finally, IFN-γ proved its usefulness to rapidly eradicate bTB at a herd-level.
PB BioMedCentral
SN 1746-6148
YR 2012
FD 2012-06-29
LK https://hdl.handle.net/20.500.14352/45167
UL https://hdl.handle.net/20.500.14352/45167
LA eng
NO Unión Europea. FP7
DS Docta Complutense
RD 10 sept 2024