RT Journal Article
T1 The Acinetobacter baumannii Omp33-36 Porin Is a Virulence Factor That Induces Apoptosis and Modulates Autophagy in Human Cells
A1 Rumbo, Carlos
A1 Tomás, María
A1 Fernández Moreira, Esteban
A1 Cruz Soares, Nelson
A1 Carvajal, Micaela
A1 Santillana, Elena
A1 Beceiro, Alejandro
A1 Romero, Antonio
A1 Bou, Germán
AB Acinetobacter baumannii is an extracellular opportunistic human pathogen that is becoming increasingly problematic in hospi-tals. In the present study, we demonstrate that the A. baumannii Omp 33- to 36-kDa protein (Omp33-36) is a porin that acts as achannel for the passage of water. The protein is found on the cell surface and is released along with other porins in the outermembrane vesicles (OMVs). In immune and connective cell tissue, this protein induced apoptosis by activation of caspases andmodulation of autophagy, with the consequent accumulation of p62/SQSTM1 (sequestosome 1) and LC3B-II (confirmed by useof autophagy inhibitors). Blockage of autophagy enables the bacterium to persist intracellularly (inside autophagosomes), withthe subsequent development of cytotoxicity. Finally, we used macrophages and a mouse model of systemic infection to confirmthat Omp33-36 is a virulence factor in A. baumannii. Overall, the study findings show that Omp33-36 plays an important role inthe pathogenesis of A. baumannii infections.
PB ASM
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/124930
UL https://hdl.handle.net/20.500.14352/124930
LA eng
NO Rumbo, Carlos, et al. «The Acinetobacter Baumannii Omp33-36 Porin Is a Virulence Factor That Induces Apoptosis and Modulates Autophagy in Human Cells». Infection and Immunity, editado por C. R. Roy, vol. 82, n.o 11, noviembre de 2014, pp. 4666-80. DOI.org (Crossref), https://doi.org/10.1128/IAI.02034-14.
NO Unión Europea
DS Docta Complutense
RD 18 dic 2025