RT Journal Article
T1 Endocannabinoid signaling in glioma
A1 Costas Insúa, Carlos
A1 Guzmán, Manuel
AB High-grade gliomas constitute the most frequent and aggressive form of primarybrain cancer in adults. These tumors express cannabinoid CB1and CB2receptors, aswell as other elements of the endocannabinoid system. Accruing preclinical evidencesupports that pharmacological activation of cannabinoid receptors located on gliomacells exerts overt anti-tumoral effects by modulating key intracellular signaling path-ways. The mechanism of this cannabinoid receptor-evoked anti-tumoral activity inexperimental models of glioma is intricate and may involve an inhibition not only ofcancer cell survival/proliferation, but also of invasiveness, angiogenesis, and the stemcell-like properties of cancer cells, thereby affecting the complex tumor microenvi-ronment. However, the precise biological role of the endocannabinoid system in thegeneration and progression of glioma seems very context-dependent and remainslargely unknown. Increasing our basic knowledge on how (endo)cannabinoids act onglioma cells could help to optimize experimental cannabinoid-based anti-tumoraltherapies, as well as the preliminary clinical testing that is currently underway.
PB Wiley-VCH
SN 0894-1491
YR 2022
FD 2022-03-24
LK https://hdl.handle.net/20.500.14352/71580
UL https://hdl.handle.net/20.500.14352/71580
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2022)
NO Ministerio de Ciencia e Innovación (MICINN)/FEDER
NO Instituto de Salud Carlos III (ISCIII)
NO Ministerio de Universidades
DS Docta Complutense
RD 19 mar 2026