RT Journal Article
T1 Consumption of a Mango Fruit Powder Protects Mice from High-Fat Induced Insulin Resistance and Hepatic Fat Accumulation
A1 Sabater, Agustín G.
A1 Ribot, Joan
A1 Priego Cuadra, Teresa
A1 Vazquez, Itxaso
A1 Frank, Sonja
A1 Palou, Andreu
A1 Buchwald-Werner, Sybille
AB Background/Aims: The aim of this study was to gain more insight into the beneficial effects of mango fruit powder on the early metabolic adverse effects of a high-fat diet. Methods: The progressive dose-response effects of mango fruit powder on body composition, circulating parameters, and the expression of genes related to fatty acid oxidation and insulin sensitivity in key tissues were studied in mice fed a moderate (45%) high-fat diet. Results: Findings suggest that mango fruit powder exerts physiological protective effects in the initial steps of insulin resistance and hepatic lipid accumulation induced by a high-fat diet in mice. Moreover, AMPK and SIRT1 appear as key regulators of the observed improvement in fatty acid oxidation capacity, as well as of the improved insulin sensitivity and the increased glucose uptake and metabolism through the glycolytic pathway capacity in liver and skeletal muscle. Conclusion: In summary, this study provides evidence that the functional food ingredient (CarelessTM) from mango fruit prevents early metabolic alterations caused by a high-fat diet in the initial stages of the metabolic syndrome.
PB Cell Physiol Biochem Press GmbH & Co KG
SN 1015-8987
YR 2017
FD 2017-06-05
LK https://hdl.handle.net/20.500.14352/121608
UL https://hdl.handle.net/20.500.14352/121608
LA eng
NO Sabater AG, Ribot J, Priego T, Vazquez I, Frank S, Palou A, et al. Consumption of a Mango Fruit Powder Protects Mice from High-Fat Induced Insulin Resistance and Hepatic Fat Accumulation. Cellular Physiology and Biochemistry. 2017;42(2):564-78.
DS Docta Complutense
RD 19 mar 2026