RT Journal Article
T1 In vitro activities of Gemifloxacin versus five quinolones and two macrolides against 271 spanish isolates of Legionella pneumophila: influence of charcoal on susceptibility test results
A1 García Esteban, María Teresa
A1 Pelaz, C.
A1 Giménez, M.J.
A1 Aguilar, L.
AB The MICs at which 90% of isolates are inhibited for gemifloxacin, trovafloxacin, and grepafloxacin were low (≤0.01 μg/ml) for 271Legionella isolates when they were determined by the broth microdilution method but increased (≥6 dilutions) when they were determined by the agar dilution method. This was due to the charcoal in the agar dilution medium, as shown by the progressive decrease in the MICs when the charcoal concentrations decreased. As free drug is the active fraction, charcoal binding should be considered.
PB ASM journals
SN 0066-4804
YR 2000
FD 2000
LK https://hdl.handle.net/20.500.14352/125468
UL https://hdl.handle.net/20.500.14352/125468
LA eng
NO García, M. T., et al. «In Vitro Activities of Gemifloxacin versus Five Quinolones and Two Macrolides against 271 Spanish Isolates of Legionella Pneumophila : Influence of Charcoal on Susceptibility Test Results». Antimicrobial Agents and Chemotherapy, vol. 44, n.o 8, agosto de 2000, pp. 2176-78. DOI.org (Crossref), https://doi.org/10.1128/AAC.44.8.2176-2178.2000.
NO This study was supported by a grant from SmithKline Beecham Pharmaceuticals, Harlow, United Kingdom.
NO SmithKline Beecham Pharmaceuticals
DS Docta Complutense
RD 24 mar 2026