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T1 The Large-Conductance, Calcium-Activated Potassium Channel: A Big Key Regulator of Cell Physiology
A1 Sancho González, María
A1 Kyle, Barry D.
AB Large-conductance Ca2+-activated K+ channels facilitate the efflux of K+ ions from a variety of cells and tissues following channel activation. It is now recognized that BK channels undergo a wide range of pre- and post-translational modifications that can dramatically alter their properties and function. This has downstream consequences in affecting cell and tissue excitability, and therefore, function. While finding the “silver bullet” in terms of clinical therapy has remained elusive, ongoing research is providing an impressive range of viable candidate proteins and mechanisms that associate with and modulate BK channel activity, respectively. Here, we provide the hallmarks of BK channel structure and function generally, and discuss important milestones in the efforts to further elucidate the diverse properties of BK channels in its many forms.
PB Frontiers Media
SN 1664-042X
YR 2021
FD 2021-10-21
LK https://hdl.handle.net/20.500.14352/120862
UL https://hdl.handle.net/20.500.14352/120862
LA eng
NO Sancho M, Kyle BD. The Large-Conductance, Calcium-Activated Potassium Channel: A Big Key Regulator of Cell Physiology. Front Physiol. 2021 Oct 21;12:750615.
DS Docta Complutense
RD 18 mar 2026