%0 Journal Article
%A San Román, Jesus
%A Carricondo Orejana, Francisco Javier
%A Iglesias Moreno, María Cruz
%A Martín-Villares, Cristina
%A Poch Broto, Joaquín
%A Gil Loyzaga, Pablo
%T Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
%D 2012
%@ 0001-6489
%U https://hdl.handle.net/20.500.14352/93504
%X Conclusion: The cochlear perilymphatic perfusion produces, by itself, significant effects in the cochlear physiology that could be associated with the surgical procedure. These effects need to be well characterized to allow a reliable quantification of the effects of the experimental agent being tested.Objectives: The study focused on the accurate description of the electrophysiological effects on the cochlear potential recordings of perilymphatic perfusions.Methods: Two successive cochlear perilymphatic perfusions were carried out. The first used artificial perilymph. The second used artificial perilymph alone or a kainic acid (KA) solution in artificial perilymph. The compound action potential of the auditory nerve (CAP-AN) was recorded: (1) before the first perfusion, (2) after the first perfusion and (3) after the second perfusion, and compared between groups.Results: The first intracochlear perfusion with artificial perilymph produced significant effects in the CAP-AN that could be related to the surgical procedure. These effects were analysed separately from the effects produced by the KA. In particular, the KA administered intracochlearly produced a significant increase in the latency and a decrease in the amplitude of the CAP-AN N1 wave compared with the controls that were perfused twice with artificial perilymph.
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