RT Journal Article
T1 Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions
A1 San Román, Jesus
A1 Carricondo Orejana, Francisco Javier
A1 Iglesias Moreno, María Cruz
A1 Martín-Villares, Cristina
A1 Poch Broto, Joaquín
A1 Gil Loyzaga, Pablo
AB Conclusion: The cochlear perilymphatic perfusion produces, by itself, significant effects in the cochlear physiology that could be associated with the surgical procedure. These effects need to be well characterized to allow a reliable quantification of the effects of the experimental agent being tested.Objectives: The study focused on the accurate description of the electrophysiological effects on the cochlear potential recordings of perilymphatic perfusions.Methods: Two successive cochlear perilymphatic perfusions were carried out. The first used artificial perilymph. The second used artificial perilymph alone or a kainic acid (KA) solution in artificial perilymph. The compound action potential of the auditory nerve (CAP-AN) was recorded: (1) before the first perfusion, (2) after the first perfusion and (3) after the second perfusion, and compared between groups.Results: The first intracochlear perfusion with artificial perilymph produced significant effects in the CAP-AN that could be related to the surgical procedure. These effects were analysed separately from the effects produced by the KA. In particular, the KA administered intracochlearly produced a significant increase in the latency and a decrease in the amplitude of the CAP-AN N1 wave compared with the controls that were perfused twice with artificial perilymph.
PB Taylor & Francis
SN 0001-6489
YR 2012
FD 2012-09-01
LK https://hdl.handle.net/20.500.14352/93504
UL https://hdl.handle.net/20.500.14352/93504
LA eng
NO San Román, J., Carricondo, F., Iglesias-Moreno, M. C., Martín-Villares, C., Poch-Broto, J., & Gil-Loyzaga, P. (2012). Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions. Acta oto-laryngologica, 132(9), 916–922. https://doi.org/10.3109/00016489.2012.678945
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 18 jul 2024