RT Journal Article
T1 Prevalence, Risk Factors and Potential Protective Strategies for Hypomagnesemia in Kidney Transplant Recipients
A1 Riaza Ortiz, Cristina
A1 Fernández Fernández, Carlos
A1 Pujol Pujol, Marina
A1 Muñiz Rincón, María
A1 Aiffil Meneses, Arianne Sofía
A1 Pérez Flores, Isabel María
A1 Calvo Romero, Natividad
A1 Moreno de la Higuera, María Ángeles
A1 Rodríguez Cubillo, Beatriz
A1 Ramos Corral, Raquel
A1 Sánchez Fructuoso, Ana Isabel
AB Hypomagnesemia is the most common electrolyte disorder in kidney transplant recipients (KTR), yet its causes remain unclear. Few studies have explored its underlying factors. This study aimed to assess its prevalence and identify risk factors in KTR. We conducted a retrospective cross-sectional study in 489 outpatient KTR. Demographic, clinical, and laboratory data were collected. Univariate and multivariate logistic regression analyses were used to identify factors associated with hypomagnesemia (≤1.7 mg/dL). Hypomagnesemia was present in 50.7% of patients. Multivariate analysis identified tacrolimus [OR 2.91 (1.62–5.22)], thiazides [OR 2.23 (1.21–4.08)], cinacalcet [OR 2.31 (1.29–4.13)], serum phosphate < 3.7 mg/dL [1.99 (1.29–3.05)], serum calcium ≤ 10 mg/dL [1.99 (1.29–3.05)] and diabetes [1.94 (1.22–3.08)] as risk factors. Protective factors included SGLT2 inhibitors (SGLT2i) [OR 0.17 (0.10–0.27)] and mTOR inhibitors (mTORi) [OR 0.62 (0.38–0.98)]. Among hypomagnesemic patients, those receiving Mg2+ supplements had lower Mg2+ levels [1.54 (0.15) vs. 1.59 (0.13) mg/dL, p = 0.005] and higher fractional Mg2+ excretion [8.28 (4.48)% vs. 7.36 (4.19)%, p = 0.05]. Hypomagnesemia is highly prevalent in KTR. Tacrolimus, thiazides, and cinacalcet are key risk factors and, in some patients, risks and benefits of continuing these medications should be carefully weighed. In refractory cases, SGLT2i or mTORi may offer benefit.
PB MDPI
SN 1661-6596
YR 2025
FD 2025-07-07
LK https://hdl.handle.net/20.500.14352/126442
UL https://hdl.handle.net/20.500.14352/126442
LA eng
NO Riaza Ortiz C, Fernández Fernández C, Pujol Pujol M, Muñiz Rincón M, Aiffil Meneses AS, Pérez Flores IM, Calvo Romero N, Moreno de la Higuera MÁ, Rodríguez Cubillo B, Ramos Corral R, Sánchez Fructuoso AI. Prevalence, Risk Factors and Potential Protective Strategies for Hypomagnesemia in Kidney Transplant Recipients. Int J Mol Sci. 2025 Jul 7;26(13):6528. doi: 10.3390/ijms26136528
DS Docta Complutense
RD 20 ene 2026