RT Journal Article
T1 Iron supplementation in mouse expands cellular innate defences in spleen and defers lethal malaria infection
A1 Azcárate, Isabel
A1 Sánchez-Jaut, Sandra
A1 Marín-García, Particia
A1 Linares, María
A1 Pérez-Benavente, Susana
A1 García-Sánchez, Marta
A1 Uceda, Javier
A1 Kamali, Ali
A1 Morán-Jiménez, María-Josefa
A1 Puyet Catalina, Antonio
A1 Díez Martín, Amalia
A1 Bautista Santa Cruz, José Manuel
AB The co-endemicity of malnutrition, erythrocytopathies, transmissible diseases and iron-deficiency contribute to the prevalence of chronic anaemia in many populations of the developing world. Although iron dietary supplementation is applied or recommended in at risk populations, its use is controversial due to undesirable outcomes, particularly regarding the response to infections, including highly prevalent malaria. We hypothesized that a boosted oxidative stress due to iron supplementation have a similar impact on malaria to that of hereditary anaemias, enhancing innate response and conditioning tissues to prevent damage during infection. Thus, we have analysed antioxidant and innate responses against lethal Plasmodium yoelii during the first five days of infection in an iron-supplemented mouse. This murine model showed high iron concentration in plasma with upregulated expression of hemoxygenase-1. The sustained homeostasis after this extrinsic iron conditioning, delayed parasitemia growth that, once installed, developed without anaemia. This protection was not conferred by the intrinsic iron overload of hereditary hemochromatosis. Upon iron-supplementation, a large increase of the macrophages/dendritic cells ratio and the antigen presenting cells was observed in the mouse spleen, independently of malaria infection. Complementary, malaria promoted the splenic B and T CD4 cells activation. Our results show that the iron supplementation in mice prepares host tissues for oxidative-stress and induces unspecific cellular immune responses, which could be seen as an advantage to promote early defences against malaria infection.
PB Elsevier
SN 0925-4439
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/98057
UL https://hdl.handle.net/20.500.14352/98057
LA eng
NO Azcárate, I. G., Sánchez-Jaut, S., Marín-García, P., Linares, M., Pérez-Benavente, S., García-Sánchez, M., Uceda, J., Kamali, A. N., Morán-Jiménez, M. J., Puyet, A., Diez, A., & Bautista, J. M. (2017). Iron supplementation in mouse expands cellular innate defences in spleen and defers lethal malaria infection. Biochimica et biophysica acta. Molecular basis of disease, 1863(12), 3049–3059. https://doi.org/10.1016/j.bbadis.2017.09.027
NO Fundación Ramón Areces
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 10 abr 2025