RT Journal Article
T1 The mu (μ) and delta (δ) opioid receptors modulate boar sperm motility
A1 Vicente Carrillo, Alejandro
A1 Álvarez Rodríguez, Manuel
A1 Rodríguez Martínez, Heriberto
AB Endogenous and exogenous opioids modulate reproductive functions in target cells via opioid receptors (μ, δ, and κ). Sperm motility is a metric of gamete functionality, and serves as a suitable parameter for in vitro drug-induced toxicity assays. This study identifies the presence and location of opioid receptors in pig spermatozoa as well as their functional response after in vitro challenge with known agonists (morphine [μ]; [D-Pen 2,5]-enkephanile [δ]; and U 50488 [κ]) and antagonists (naloxone [μ]; naltrindole [δ]; and nor-binaltrorphimine [κ]). Only the μ- and δ-opioid receptors were present in the boar sperm plasma membrane, overlying the acrosome, neck, and principal piece. Challenge experiments with agonists and antagonists identified both μ- and δ-opioid receptors as regulators of sperm kinematics, wherein μ maintains or increases sperm movement whereas δ decreases sperm motility over time.
PB Wiley
SN 1040-452X
YR 2016
FD 2016-07-08
LK https://hdl.handle.net/20.500.14352/104453
UL https://hdl.handle.net/20.500.14352/104453
LA eng
NO Vicente-Carrillo, A., Álvarez-Rodríguez, M. and Rodríguez-Martínez, H. (2016), The mu (μ) and delta (δ) opioid receptors modulate boar sperm motility. Mol. Reprod. Dev., 83: 724-734. https://doi.org/10.1002/mrd.22675
DS Docta Complutense
RD 9 abr 2025