RT Journal Article
T1 NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
A1 Cores Esperón, Ángel
A1 Piquero Martí, Marta
A1 Villacampa Sanz, Mercedes
A1 León Martínez, Rafael
A1 Menéndez Ramos, José Carlos
AB NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.
PB MDPI
SN 2218-273X
YR 2020
FD 2020-06-14
LK https://hdl.handle.net/20.500.14352/8385
UL https://hdl.handle.net/20.500.14352/8385
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
NO Instituto de Salud Carlos III (ISCIII)/FEDER
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 1 oct 2024