RT Journal Article
T1 A Prospective Study of the Serological, Clinical, and Epidemiological Features of a SARS-CoV-2 Positive Pediatric Cohort
A1 Callejas Caballero, Ignacio
A1 Ruedas López, Alba
A1 Berzosa Sánchez, Arantxa
A1 Illán Ramos, Marta
A1 Joyanes Abancens, Belén
A1 Bodas Pinedo, Andrés
A1 Guillén Martín, Sara
A1 Soto Sánchez, Beatriz
A1 García Bermejo, Isabel
A1 Molina Arana, David
A1 Alós, Juan-Ignacio
A1 Baos Muñoz, Elvira
A1 Delgado Iribarren, Alberto
A1 Fuentes Ferrer, Manuel E.
A1 Ramos Amador, José Tomás
AB Background: SARS-CoV-2 was a global pandemic. Children develop a mild disease and may have a different rate of seroconversion compared to adults. The objective was to determine the number of seronegative patients in a pediatric cohort. We also reviewed the clinical–epidemiological features associated with seroconversion. Methods: A multicenter prospective observational study during September–November 2020, of COVID-19, confirmed by reverse transcription-polymerase chain reaction. Data were obtained 4–8 weeks after diagnosis. Blood samples were collected to investigate the humoral response, using three different serological methods. Results: A total of 111 patients were included (98 symptomatic), 8 were admitted to hospital, none required an Intensive Care Unit visit. Median age: 88 months (IQR: 24–149). Median time between diagnosis and serological test: 37 days (IQR: 34–44). A total of 19 patients were non-seroconverters when using three serological techniques (17.1%; 95% CI: 10.6–25.4); most were aged 2–10 years (35%, p < 0.05). Univariate analysis yielded a lower rate of seroconversion when COVID-19 confirmation was not present amongst household contacts (51.7%; p < 0.05). Conclusions: There was a high proportion of non-seroconverters. This is more commonly encountered in childhood than in adults. Most seronegative patients were in the group aged 2–10 years, and when COVID-19 was not documented in household contacts. Most developed a mild disease. Frequently, children were not the index case within the family.
PB MPDI
SN 2227-9067
YR 2022
FD 2022-05-05
LK https://hdl.handle.net/20.500.14352/71623
UL https://hdl.handle.net/20.500.14352/71623
LA eng
DS Docta Complutense
RD 24 abr 2025