RT Journal Article
T1 Female mice reaching exceptionally high old age havepreserved 20S proteasome activities
A1 Martínez de Toda Cabeza, Irene
A1 Rattan, Suresh I. S.
A1 Fuente del Rey, Mónica de la
A1 Arranz Salas, Lorena
AB Oxidized, damaged and misfolded proteins accumulate during aging and contribute to impaired cell function and tissue homeodynamics. Damaged proteins are degraded by cellular clearance mechanisms like the 20S proteasome. Aging relates to low 20S proteasome function, whereas long-lived species show high levels. However, contradictory results exist depending on the tissue or cell type and it is unknown how the 20S proteasome functions in exceptionally old mice. The aim of this study was to investigate two proteasome activities (caspase-like and chymotrypsin-like) in several tissues (lung, heart, axillary lymph nodes, liver, kidney) and cells (peritoneal leukocytes) from adult (28 ± 4 weeks, n = 12), old (76 ± 4 weeks, n = 9) and exceptionally old (128 ± 4 weeks, n = 9) BALB/c female mice. The results show different age-related changes depending on the tissue and the activity considered, so there is no universal decline in proteasome function with age in female mice. Interestingly, exceptionally old mice displayed better maintained proteasome activities, suggesting that preserved 20S proteasome is associated with successful aging.
PB MDPI
SN Electronic: 2076-3921
YR 2021
FD 2021-08-31
LK https://hdl.handle.net/20.500.14352/4771
UL https://hdl.handle.net/20.500.14352/4771
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de Salud Carlos III (ISCIII)/Fondo Europeo de Desarrollo Regional(FEDER)
NO Universidad Complutense de Madrid
NO Northern Norway Regional Health Authority and UiT
NO Research Council of Norway
NO Norwegian Cancer Society
DS Docta Complutense
RD 15 may 2024