%0 Journal Article
%A Alou Cervera, Luis
%A Cafini, Fabio
%A Sevillano Fernández, David
%A Unzueta, Irune
%A Prieto Prieto, José
%T In vitro activity of mupirocin and amoxicillin-clavulanate alone and in combination against staphylococci including those resistant to methicillin
%D 2004
%@ 0924-8579
%U https://hdl.handle.net/20.500.14352/107056
%X Mupirocin and amoxicillin-clavulanate were synergistic against 9 of 49 (18%) strains of methicillin-resistant and methicillin-susceptible Staphylococcus aureus and coagulase-negative staphylococci (CNS). A pattern of enhanced killing was also found using time-kill studies. Time-kill assays were more discriminatory than chequerboard titration assays in demonstrating synergy. These results suggest that combinations of amoxicillin-clavulanate and mupirocin may have therapeutic benefits in prophylaxis against staphylococcal infections.
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