RT Journal Article
T1 Predictive Models of Life Span in Old Female Mice Based on Immune, Redox, and Behavioral Parameters
A1 Félix Escalera, Judith
A1 Martínez De Toda Cabeza, Irene
A1 Díaz Del Cerro, Estefanía
A1 Sánchez Del Pozo, Iris
A1 Fuente Del Rey, María Mónica De La
AB The development of mathematical models capable of predicting the lifespan of animals is growing. However, there are no studies that compare the predictive power of different sets of parameters depending on the age of the animals. The aim of the present study is to test whether mathematical models for life span prediction developed in adult female mice based on immune, redox, and behavioral parameters can predict life span in old animals and to develop new models in old mice. For this purpose, 29 variables, including parameters of immune function, redox state, and behavioral ones, were evaluated in old female Swiss mice (80 ± 4 weeks). Life span was registered when they died naturally. Firstly, we observed that the models developed in adults were not able to accurately predict the life span of old mice. Therefore, the immunity (adjusted R2 = 73.6%), redox (adjusted R2 = 46.5%), immunity-redox (adjusted R2 = 96.4%), and behavioral (adjusted R2 = 67.9%) models were developed in old age. Finally, the models were validated in another batch of mice. The developed models in old mice show certain similarities to those in adults but include different immune, redox, and behavioral markers, which highlights the importance of age in the prediction of life span.
PB MDPI
SN 1661-6596
YR 2024
FD 2024-04-10
LK https://hdl.handle.net/20.500.14352/118963
UL https://hdl.handle.net/20.500.14352/118963
LA eng
NO Félix, J., Martínez de Toda, I., Díaz-Del Cerro, E., Sánchez-Del Pozo, I., & De la Fuente, M. (2024). Predictive Models of Life Span in Old Female Mice Based on Immune, Redox, and Behavioral Parameters. International Journal of Molecular Sciences, 25(8), 4203. https://doi.org/10.3390/ijms25084203
NO This research was funded by the Research Group UCM (910379).
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 9 abr 2025