RT Journal Article
T1 First Insights into the Biological Activity and Molecular Docking of Citral (3,7-Dimethyl-2,6-Octadienal) Against Trichomonas vaginalis.
A1 Ibáñez Escribano, Alexandra
A1 Mello, A.B.
A1 Fenalti, J.M.
A1 Baccega, B
A1 Wahast Islabão, Y.
A1 Martins, F. O.
A1 Birmann, P. T.
A1 Casaril, A. M.
A1 Barbosa, T. N.
A1 Sena-Lopes, A.
A1 Monteiro, F. L.
A1 Savegnago, L.
A1 Borsuk, S.
A1 Hubner, S. d. O.
A1 Farias, N. d. A. d. R
A1 Ibáñez-Escribano, Alexandra
A1 Oliveira, C. B.
AB The increasing resistance of Trichomonas vaginalis to the only approved chemical family of drugs for treatment, the 5-nitroimidazoles, has prompted the exploration of new therapeutic agents against this prevalent non-viral sexually transmitted infection. Natural products have emerged as a significant source of novel treatments for trichomoniasis. The aim of this study was to evaluate the anti-T. vaginalis activity of citral (3,7-dimethyl-2,6-octadienal), the main constituent of the essential oil of Cymbopogon species, commonly known as lemongrass. Our findings indicate that citral exhibits a minimum inhibitory concentration (MIC) of 100 μM, effectively inhibiting the growth of T. vaginalis trophozoites within 12 h of exposure, and a 50% inhibitory concentration (IC50) of approximately 40 μM after 24 h. Furthermore, the evaluation of nitric oxide (NO) levels suggests that citral possesses antioxidant properties. Molecular docking studies reveal a weak interaction with three parasite proteins: thioredoxin reductase (TvTrxR), purine nucleoside phosphorylase (TvPNP), and methionine gamma lyase (TvMGL). The present study highlights the potential of citral as a candidate for the development of no-nitroimidazole drugs, offering new avenues for trichomoniasis treatment and underscoring the importance of further investigation into citral’s mechanism of action.
PB MDPI
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/122254
UL https://hdl.handle.net/20.500.14352/122254
LA eng
NO Mello, A.B.d.; Fenalti, J.M.; Baccega, B.; Wahast Islabão, Y.; Martins, F.O.; Birmann, P.T.; Casaril, A.M.; Barbosa, T.N.; Sena-Lopes, A.; Monteiro, F.L.; et al. First Insights into the Biological Activity and Molecular Docking of Citral (3,7-Dimethyl-2, 6-Octadienal) Against Trichomonas vaginalis. Microbiol. Res. 2025, 16, 96. https://doi.org/10.3390/ microbiolres16050096
NO Apoio a Pós-Graduação (PROAP)
NO Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
DS Docta Complutense
RD 11 jul 2025