RT Journal Article
T1 Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection
A1 Rodríguez Pérez, Laura
A1 Ramos-Soriano, Javier
A1 Pérez Sánchez, Alfonso
A1 Illescas Martínez, Beatriz María
A1 Muñoz, Antonio
A1 Luczkowiak, Joanna
A1 Lasala, Fátima
A1 Rojo, Javier
A1 Delgado Vázquez, Rafael
A1 Martín León, Nazario
AB SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC “click chemistry” approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.
PB American Chemical Society
SN 0002-7863
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/92801
UL https://hdl.handle.net/20.500.14352/92801
LA eng
NO Rodríguez-Pérez, L.; Ramos-Soriano, J.; Pérez-Sánchez, A.; Illescas, B. M.; Muñoz, A.; Luczkowiak, J.; Lasala, F.; Rojo, J.; Delgado, R.; Martín, N. Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection. J. Am. Chem. Soc. 2018, 140, 9891-9898 DOI:10.1021/jacs.8b03847.
DS Docta Complutense
RD 10 abr 2025