%0 Journal Article
%A Abad Martínez, María José
%A Bermejo Benito, Paulina
%A Álvarez, Maria
%A Guerra Guirao, José Antonio
%A Silván, Ana María
%A Villar Del Fresno, Ángel
%T Flavonoids and a Sesquiterpene Lactone from Tanacetum microphyllum Inhibit Anti-Inflammatory Mediators in LPS-Stimulated Mouse Peritoneal Macrophages
%D 2004
%U https://hdl.handle.net/20.500.14352/134062
%X In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3′-dihydroxy-4′-methoxy-7- methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibitors of some macrophage functions involved in the inflammatory process. These five compounds significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) in a concentration-dependent manner. In the tumour necrosis factor-α (TNF-α) assay, only centaureidin and hydroxyachillin significantly inhibited the accumulation of TNF-α. These results indicate that these compounds may contribute to the anti-inflammatory properties of T. microphyllum.
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