RT Journal Article
T1 Flavonoids and a Sesquiterpene Lactone from Tanacetum microphyllum Inhibit Anti-Inflammatory Mediators in LPS-Stimulated Mouse Peritoneal Macrophages
A1 Abad Martínez, María José
A1 Bermejo Benito, Paulina
A1 Álvarez, Maria
A1 Guerra Guirao, José Antonio
A1 Silván, Ana María
A1 Villar Del Fresno, Ángel
AB In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3′-dihydroxy-4′-methoxy-7- methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibitors of some macrophage functions involved in the inflammatory process. These five compounds significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) in a concentration-dependent manner. In the tumour necrosis factor-α (TNF-α) assay, only centaureidin and hydroxyachillin significantly inhibited the accumulation of TNF-α. These results indicate that these compounds may contribute to the anti-inflammatory properties of T. microphyllum.
PB Thieme Group
YR 2004
FD 2004
LK https://hdl.handle.net/20.500.14352/134062
UL https://hdl.handle.net/20.500.14352/134062
LA eng
NO Flavonoids and a Sesquiterpene Lactone from Tanacetum microphyllum Inhibit Anti-Inflammatory Mediators in LPS-Stimulated Mouse Peritoneal Macrophages. Planta med. enero de 2004;70(1):34-8. doi:10.1055/s-2004-815452
DS Docta Complutense
RD 19 mar 2026