RT Journal Article
T1 Dynamic energy budget approach to evaluate antibiotic effects on biofilms
A1 Birnir, Bjorn
A1 Carpio Rodríguez, Ana María
A1 Cebrián, Elena
A1 Vidal Lloret, Perfecto
AB Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix. Coupling a dynamic energy budget based description of cell metabolism to surrounding concentration fields, we are able to approximate survival curves measured for different antibiotics. We reproduce numerically stratified distributions of cell types within the biofilm and introduce ways to incorporate different resistance mechanisms. Qualitative predictions follow that are in agreement with experimental observations, such as higher survival rates of cells close to the substratum when employing antibiotics targeting active cells or enhanced polymer production when antibiotics are administered. The current computational model enables validation and hypothesis testing when developing therapies.
PB Elsevier
SN 1007-5704
YR 2018
FD 2018-01
LK https://hdl.handle.net/20.500.14352/13408
UL https://hdl.handle.net/20.500.14352/13408
LA eng
NO Birnir, B., Carpio Rodríguez, A. M., Cebrián, E., Vidal Lloret, P. «Dynamic Energy Budget Approach to Evaluate Antibiotic Effects on Biofilms». Communications in Nonlinear Science and Numerical Simulation, vol. 54, enero de 2018, pp. 70-83. DOI.org (Crossref), https://doi.org/10.1016/j.cnsns.2017.05.016.
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 20 abr 2025