RT Journal Article
T1 Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair
A1 Azcutia Criado, Verónica
A1 Birkl, Dorothee
A1 O’Leary, Monique N.
A1 Quiros, Miguel
A1 Schaller, Matthew
A1 Reed, Michelle
A1 Nishio, Hikaru
A1 Keeney, Justin
A1 Neish, Andrew S.
A1 Lukacs, Nicholas W.
A1 Parkos, Charles A.
A1 Nusrat, A
AB Mucosal wound repair is coordinated by dynamic crosstalk between endogenous and exogenous mediators and specific receptors on epithelial cells and infiltrating immune cells. One class of such receptor-ligand pairs involves formyl peptide receptors (FPRs) that have been shown to influence inflammatory response and repair. Here we explored the role of murine Fpr2/3, an ortholog of human FPR2/receptor for lipoxin A4 (ALX), in orchestrating intestinal mucosal repair. Compared with wild-type (WT) mice, Fpr2/3-/- mice exhibited delayed recovery from acute experimental colitis and perturbed repair after biopsy-induced colonic mucosal injury. Decreased numbers of infiltrating monocytes were observed in healing wounds from Fpr2/3-/- mice compared with WT animals. Bone marrow transplant experiments revealed that Fpr2/3-/- monocytes showed a competitive disadvantage when infiltrating colonic wounds. Moreover, Fpr2/3-/- monocytes were defective in chemotactic responses to the chemokine CC chemokine ligand (CCL)20, which is up-regulated during early phases of inflammation. Analysis of Fpr2/3-/- monocytes revealed altered expression of the CCL20 receptor CC chemokine receptor (CCR)6, suggesting that Fpr2/3 regulates CCL20-CCR6-mediated monocyte chemotaxis to sites of mucosal injury in the gut. These findings demonstrate an important contribution of Fpr2/3 in facilitating monocyte recruitment to sites of mucosal injury to influence wound repair.-Birkl, D., O'Leary, M. N., Quiros, M., Azcutia, V., Schaller, M., Reed, M., Nishio, H., Keeney, J., Neish, A. S., Lukacs, N. W., Parkos, C. A., Nusrat, A. Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair.
PB Wiley
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/117111
UL https://hdl.handle.net/20.500.14352/117111
LA eng
NO Birkl, Dorothee, et al. «Formyl Peptide Receptor 2 Regulates Monocyte Recruitment to Promote Intestinal Mucosal Wound Repair». The FASEB Journal, vol. 33, n.o 12, diciembre de 2019, pp. 13632-43. DOI.org (Crossref), https://doi.org/10.1096/fj.201901163R.
NO National Institues of Health
NO National Institute of Diabetes and Digestive and Kidney Diseases
NO German Research Foundation (DFG)
NO Crohn’s and Colitis Foundation
DS Docta Complutense
RD 4 abr 2025