RT Journal Article
T1 Changes in Endothelial Microparticles and Endothelial Progenitor Cells in Obese Patients in Response to Surgical Stress
A1 Noci, María Victoria
A1 Ramírez, Rafael
A1 Lluch, Mercedes
A1 Rodríguez, Mariano
A1 Carracedo Añón, Julia María
AB Background: Obese patients undergoing surgery are at increased risk of intraoperative and postoperative cardiovascular complications. The present study was designed to study the changes in endothelial microparticles, endothelial progenitor cells, and adipokines in obese patients in response to limb ischemia during knee surgery.Methods: This prospective study included seventy-four patients who underwent total knee arthroplasty. Patients were stratified in tertiles according to their body mass index. Flow cytometry was used for quantification and characterization of endothelial microparticles, endothelial progenitor cells, and adipokines. ELISA (enzyme-linked immunosorbent assay) was used to measure the adiponectin level.Results: The number of endothelial microparticles was greater in obese compared with nonobese patients. The number of endothelial microparticles increased further immediately after surgery in all tertiles. Three days after surgery, endothelial microparticles returned to the basal preoperative level except in the most obese patients. The percentage of endothelial progenitor cells was lower in obese patients. Concentrations of adipokines increased after surgery, but the increase was more accentuated in obese patients.Conclusions: Obese patients present with a high number of endothelial microparticles, a low number of endothelial progenitor cells, and high levels of adipokines, with further increases in adipokines after surgery, suggesting an inflammatory condition that worsens after surgery and may affect endothelial repair.
PB The Journal of Bone and Joint Surgery, Incorporated.
SN 0021-9355
YR 2015
FD 2015-03-04
LK https://hdl.handle.net/20.500.14352/131836
UL https://hdl.handle.net/20.500.14352/131836
LA eng
NO Noci, G., Ramírez, J. M., et al. (2015). Changes in endothelial microparticles and endothelial progenitor cells in obese patients in response to surgical stress. The Journal of Bone & Joint Surgery, 97(5), e30. https://doi.org/10.2106/JBJS.N.00570
NO No funding or acknowledgments
DS Docta Complutense
RD 19 mar 2026