RT Journal Article
T1 P50 sensory gating is a trait marker of the bipolar spectrum
A1 Cabranes Díaz, José Antonio
A1 Ancín, Inés
A1 Santos Gómez, José Luis
A1 Sánchez-Morla, Eva María
A1 García-Jiménez, María A
A1 Rodríguez-Moya, Laura
A1 Fernández Pérez, Crsitina
A1 Barabash Bustelo, Ana
A1 Cabranes Díaz, José Antonio
A1 Sánchez Morla, Eva María
A1 Barabash Bustelo, Ana
AB Sensory gating deficit, assessed by a paired auditory stimulus paradigm (P50), has been reported as a stable marker of schizophrenia. The aim of this study was to explore if this neurophysiological disturbance also fulfilled stability criteria in the bipolar disorder (BD) spectrum bipolar, as state independence is one of the main points to be considered as a potential endophenotype of the illness. The P50 evoked potential was studied in 95 healthy controls and 126 bipolar euthymic patients. Euthymia was established according to Van Gorp's criteria. Bipolar I and II subtypes were analyzed separately. The influence of a lifetime history of psychoses was also evaluated in the clinical sample. P50 gating was deficitary in all the subsamples of patients relative to healthy comparison subjects. Bipolar I patients with and without a history of psychosis showed higher P50 ratios than the other subgroups of patients, although these differences were not significant. P50 alterations were mainly due to a deficit in the inhibition of the second wave (test wave or S2) amplitude. Conclusions: The findings suggest that this inhibitory deficit can be considered characteristic of the illness and that the intensity of the gating abnormality varies according to the severity of BD
PB Elsevier
SN 0924-977X
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/115061
UL https://hdl.handle.net/20.500.14352/115061
LA eng
NO Cabranes JA, Ancín I, Santos JL, Sánchez-Morla E, García-Jiménez MA, Rodríguez-Moya L, et al. P50 sensory gating is a trait marker of the bipolar spectrum. European Neuropsychopharmacology 2013;23:721–7. https://doi.org/10.1016/j.euroneuro.2012.06.008.
NO Ministerio de Ciencias, Innovación y Universidades,Instituto de Salud Carlos III, Fundación Mutua Madrileña, Instituto de Ciencias de la Salud de Castilla la Mancha
DS Docta Complutense
RD 10 abr 2025