%0 Journal Article
%A Barrio, Manuel de
%A Tornero Molina, Pilar
%A Prieto, A.
%A Sainza, T.
%A Zubeldia Ortuño, José Manuel
%A Herrero, T.
%T Recurrent fixed drug eruption caused by citiolone
%D 1997
%@ 1018-9068
%U https://hdl.handle.net/20.500.14352/95775
%X Citiolone (N-acetylhomocysteinethiolactone) is a thiolic­derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolytic drugs have rarely been implicated in the fixed drug eruption etiology. We report on a patient who presented several episodes of fixed exanthema related to citiolone intake. The patch test with citiolone (10% in dimethyl sulfoxide) was negative. The diagnosis was confirmed by a positive controlled oral challenge test. Other mucolytic thiolic­derivatives (N-acetylcysteine) were tolerated by the patient, thus crossreactivity between these drugs seems to be unlikely.
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