RT Journal Article
T1 Recurrent fixed drug eruption caused by citiolone
A1 Barrio, Manuel de
A1 Tornero Molina, Pilar
A1 Prieto, A.
A1 Sainza, T.
A1 Zubeldia Ortuño, José Manuel
A1 Herrero, T.
AB Citiolone (N-acetylhomocysteinethiolactone) is a thiolic­derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolytic drugs have rarely been implicated in the fixed drug eruption etiology. We report on a patient who presented several episodes of fixed exanthema related to citiolone intake. The patch test with citiolone (10% in dimethyl sulfoxide) was negative. The diagnosis was confirmed by a positive controlled oral challenge test. Other mucolytic thiolic­derivatives (N-acetylcysteine) were tolerated by the patient, thus crossreactivity between these drugs seems to be unlikely.
PB ESMON
SN 1018-9068
YR 1997
FD 1997-05-01
LK https://hdl.handle.net/20.500.14352/95775
UL https://hdl.handle.net/20.500.14352/95775
LA eng
NO de Barrio M, Tornero P, Prieto A, Sainza T, Zubeldia JM, Herrero T. Recurrent fixed drug eruption caused by citiolone. J Investig Allergol Clin Immunol. 1997 May-Jun;7(3):193-4. PMID: 9252880.
DS Docta Complutense
RD 8 abr 2025