RT Journal Article
T1 Complement in basic processes of the cell
A1 Jiménez Reinoso, Anaïs
A1 Marín Marín, Ana Victoria
A1 Regueiro González-Barros, José Ramón
AB The complement system is reemerging in the last few years not only as key element of innate immunityagainst pathogens, but also as a main regulator of local adaptive responses, affecting dendritic cells as wellas T and B lymphocytes. We review data showing that leucocytes are capable of significant autocrine syn-thesis of complement proteins, and express a large range of complement receptors, which in turn regulatetheir differentiation and effector functions while cross talking with other innate receptors such as Toll-like receptors. Other unconventional roles of complement proteins are reviewed, including their impactin non-leukocytes and their intracellular cleavage by vesicular proteases, which generate critical cuesrequired for T cell function. Thus, leucocytes are very much aware of complement-derived information,both extracellular and intracellular, to elaborate their responses, offering rich avenues for therapeuticintervention and new hypothesis for conserved major histocompatibility complex complotypes.
PB Elsevier
SN 0161-5890, ESSN: 1872-9142
YR 2016
FD 2016-12-03
LK https://hdl.handle.net/20.500.14352/19240
UL https://hdl.handle.net/20.500.14352/19240
LA eng
NO Ministerio de Economia y Competitividad (MINECO)
NO Comunidad de Madrid
NO Universidad Complutense de Madrid/Harvard University
DS Docta Complutense
RD 17 dic 2025