%0 Journal Article
%A Deghima, Amirouche
%A Righi, Nadjat
%A Rosales Conrado, Noelia
%A León González, María Eugenia De
%A Baali, Faiza
%A Gómez Mejía, Esther
%A Madrid Albarrán, María Yolanda
%A Bedjou, Fatiha
%T Phenolic profile, safety, antioxidant and anti-inflammatory activities of wasted Bunium ferulaceum Sm. aerial parts
%D 2022
%@ 0963-9969
%U https://hdl.handle.net/20.500.14352/93594
%X The pharmaceutical and nutraceutical industries benefit greatly from recycling and transforming non-utilizedparts of medicinal plants from agro-industrial operations into value added products. Hence, the aim of thiswork was to study the potential nutraceutical and pharmaceutical applications of Bunium ferulaceum Sm. aerialparts, in order to maximize their value. The phenolic profile of their hydromethanolic extract was determinedand its antioxidant activity was evaluated in vitro and in vivo alongside with its anti-inflammatory activity andsafety profile. The extract exerted an in vitro antioxidant activity mainly through radical scavenging (DPPH IC50:14.0 ± 0.3 μg/ml) and iron chelating ability (24 ± 2 μg/ml), while, in vivo, the extract did not cause anymortality or visible signs of acute toxicity at high dose (2000 mg/kg body weight). The supplementation of theextract at different doses improved mice liver redox state by increasing catalase and reduced glutathione levelsand reducing lipid peroxidation, without causing any toxicity. Moreover, the extract efficiently inhibited xyleneinduced ear inflammation (62 %). These different bioactivities were linked to the phenolic compounds present inthe extract, particularly, chlorogenic acid (78 ± 6 mg/g extract), rutin (44 ± 2 mg/g extract) and hesperidin (56± 9 mg/g extract). However, further studies should be carried out on the isolated major compounds found in theextract to correlate the activity with these compounds or their mixture. The wasted aerial parts of Bunium ferulaceumSm. proved to be a valuable source of polyphenols and exhibited interesting health promoting effectswith no toxicity. Thus, Bunium ferulaceum Sm. aerial parts can be included in nutraceutical formulations or usedas functional food and the extracted compounds may be used as an alternative food preservative.
%~