RT Journal Article
T1 Sex Differences in COVID-19 Hospitalization and Hospital Mortality among Patients with COPD in Spain: A Retrospective Cohort Study
A1 Miguel Díez, Javier De
A1 López De Andrés, Ana Isabel
A1 Jiménez García, Rodrigo
A1 Miguel Yanes, José María De
A1 Hernández Barrera, Valentín
A1 Carabantes Alarcón, David
A1 Zamorano León, José Javier
A1 López Herranz, Marta
A1 Omaña Palanco, Ricardo
AB We aimed to assess the effect of COPD in the incidence of hospital admissions for COVID-19 and on the in-hospital mortality (IHM) according to sex. (2) Methods: We used national hospital discharge data to select persons aged ≥40 years admitted to a hospital with a diagnosis of COVID-19 in 2020 in Spain. (3) Results: The study population included 218,301 patients. Age-adjusted incidence rates of COVID-19 hospitalizations for men with and without COPD were 10.66 and 9.27 per 1000 persons, respectively (IRR 1.14; 95% CI 1.08–1.20; p < 0.001). The IHM was higher in men than in women regardless of the history of COPD. The COPD was associated with higher IHM among women (OR 1.09; 95% CI 1.01–1.22) but not among men. The COPD men had a 25% higher risk of dying in the hospital with COVID-19 than women with COPD (OR 1.25, 95% CI 1.1–1.42). (4) Conclusions: Sex differences seem to exist in the effect of COPD among patients suffering COVID-19. The history of COPD increased the risk of hospitalization among men but not among women, and COPD was only identified as a risk factor for IHM among women. In any case, we observed that COPD men had a higher mortality than COPD women. Understanding the mechanisms underlying these sex differences could help predict the patient outcomes and inform clinical decision making to facilitate early treatment and disposition decisions.
PB MDPI
SN 1999-4915
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/72249
UL https://hdl.handle.net/20.500.14352/72249
LA eng
NO Miguel Diez, J., López De Arce, A. I., Jiménez García, R. et al. «Sex Differences in COVID-19 Hospitalization and Hospital Mortality among Patients with COPD in Spain: A Retrospective Cohort Study». Viruses, vol. 14, n.o 6, junio de 2022, p. 1238. DOI.org (Crossref), https://doi.org/10.3390/v14061238.
NO Comunidad de Madrid
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 29 may 2025