RT Journal Article
T1 NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations
A1 Ear, Po Hie
A1 Marinoni, Ilaria
A1 Dayton, Talya
A1 Guenter, Rachael
A1 Dawn, E Quelle
A1 Battistella, Anna
A1 Buishand, Floryne O
A1 Chittaranjan, Suganthi
A1 Du, Yi-Cheih Nancy
A1 Marqués, Inés
A1 Pellegata, Natalia S
A1 Sadowski, Samira M
A1 Tirosh, Amit
A1 April-Monn, Simon
A1 Aurilia, Cinzia
A1 Jaskula-Sztul, Renata
A1 Baena Moreno, Maria Jesús
A1 Donati, Simone
A1 English, Katherine A
A1 Hernández Llorens, María Almudena
A1 Hodgetts, Harry
A1 Marini, Francesca
A1 Martins, Maria
A1 Palmini, Gaia
A1 Soldevilla Navarro, Beatriz
A1 Schrader, Jörg
A1 Thakker, Rajesh V
A1 Lines, Kate E
AB Current models for the study of neuroendocrine tumours (NETs) are severely limited. While in vitro (e.g. cell lines), ex vivo (e.g. organoids) and in vivo (e.g. mice) models all exist, each has limitations. To address these limitations and collectively identify strategies to move the NET models field forward, we held an inaugural NET models meeting, hosted by our founding group: Dr Lines (Oxford), Prof. Quelle (Iowa), Dr Dayton (Barcelona), Dr Ear (Iowa), Dr Marinoni (Bern) and Dr Guenter (Alabama). This two-day meeting in Oxford (UK) was organised and supported by Bioscientifica Ltd and was solely dedicated to the discussion of NET models. The meeting was attended by ∼30 international researchers (from the UK, EU, Israel, USA and Canada). Plenary talks were given by Prof. Thakker, who summarised NET research over the past few decades, and Dr Schrader, who described the process and pitfalls of generating new cell lines. Eight researchers also presented their work on topics ranging from human cell 3D bioprinting to zebrafish models and included novel ideas and improvements on current concepts. This was followed by an interactive workshop, where discussion topics included a summary of currently available NET models, limitations of these models, barriers to developing new models, and how we can address these issues going forward. This white paper summarises the key points raised in these discussions and the future aspirations of the NET Models Consortium. The next meeting will take place in Oxford (UK) in 2025; contact contact@netcancerfoundation.com for more information.
PB Bioscientifica Ltd.
SN 2634-4793
YR 2024
FD 2024-12-19
LK https://hdl.handle.net/20.500.14352/118378
UL https://hdl.handle.net/20.500.14352/118378
LA eng
NO Ear, P H, Marinoni, I, Dayton, T, Guenter, R, Quelle, D E, Battistella, A, et al. (2024). NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations. Endocrine Oncology, 4, e240055. https://doi.org/10.1530/EO-24-0055
DS Docta Complutense
RD 7 abr 2025