RT Journal Article
T1 Negative impact of HIV infection on broad-spectrum anti-HCV neutralizing antibody titers in HCV-infected patients with advanced HCV-related cirrhosis
A1 Sepúlveda-Crespo, Daniel
A1 Yélamos López, María Belén
A1 Díez, Cristina
A1 Gómez Gutiérrez, Julián
A1 Hontañón, Víctor
A1 Torresano Felipe, Francisco
A1 Berenguer, Juan
A1 González García, Juan
A1 Ibañez-Samaniego, Luis
A1 Llop, Elva
A1 Olveira, Antonio
A1 Martínez, Javier
A1 Resino, Salvador
A1 Martínez, Isidoro
AB ObjectivesThe current study aimed to assess the impact of HIV on the production of anti-HCV antibodies in HCV-infected individuals with advanced HCV-related cirrhosis before and 36 weeks after the sustained virological response (SVR) induced by direct-acting antivirals (DAAs) therapy.MethodsProspective study on 62 patients (50 HIV/HCV-coinfected and 12 HCV-monoinfected). Plasma anti-E2 and HCV-nAbs were determined respectively by ELISA and microneutralization assays.ResultsAt baseline, the HCV-group had higher anti-E2 levels against Gt1a (p = 0.012), Gt1b (p = 0.023), and Gt4a (p = 0.005) than the HIV/HCV-group. After SVR, anti-E2 titers against Gt1a (p < 0.001), Gt1b (p = 0.001), and Gt4a (p = 0.042) were also higher in the HCV-group than HIV/HCV-group. At 36 weeks post-SVR, plasma anti-E2 titers decreased between 1.3 and 1.9-fold in the HIV/HCV-group (p < 0.001) and between 1.5 and 1.8-fold in the HCV-group (p ≤ 0.001). At baseline, the HCV-group had higher titers of HCV-nAbs against Gt1a (p = 0.022), Gt1b (p = 0.002), Gt2a (p < 0.001), and Gt4a (p < 0.001) than the HIV/HCV-group. After SVR, HCV-nAbs titers against Gt1a (p = 0.014), Gt1b (p < 0.001), Gt2a (p = 0.002), and Gt4a (p = 0.004) were also higher in the HCV-group. At 36 weeks post-SVR, HCV-nAbs decreased between 2.6 and 4.1-fold in the HIV/HCV-group (p < 0.001) and between 1.9 and 4.0-fold in the HCV-group (p ≤ 0.001).ConclusionsHIV/HCV-coinfected patients produced lower levels of broad-spectrum anti-HCV antibodies than HCV-monoinfected patients.
PB Elsevier
SN 0753-3322
YR 2022
FD 2022-04-25
LK https://hdl.handle.net/20.500.14352/134815
UL https://hdl.handle.net/20.500.14352/134815
LA eng
NO Daniel Sepúlveda-Crespo, María Belén Yélamos, Cristina Díez, Julián Gómez, Víctor Hontañón, Francisco Torresano-Felipe, Juan Berenguer, Juan González-García, Luis Ibañez-Samaniego, Elva Llop, Antonio Olveira, Javier Martínez, Salvador Resino, Isidoro Martínez, Negative impact of HIV infection on broad-spectrum anti-HCV neutralizing antibody titers in HCV-infected patients with advanced HCV-related cirrhosis, Biomedicine & Pharmacotherapy, Volume 150, 2022, 113024
NO Instituto de Salud Carlos III
NO Spanish AIDS Research Network
NO CIBER -Consorcio Centro de Investigación Biomédica en Red
NO Ministerio de Ciencia e Innovación and Unión Europea – NextGenerationEU
DS Docta Complutense
RD 27 abr 2026